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KMID : 0387720130240030207
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Korean Journal of Blood Transfusion
2013 Volume.24 No. 3 p.207 ~ p.216
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Platelet Additive Solutions
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Yang Jin-Hyuk
Kwon So-Yong
Lee Ju-Yeon
Jee Yong-Hun
Kim Myung-han
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Abstract
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Storage of platelet concentrates in platelet additive solution (PAS) with plasma removal has many advantages, including reduction of allergic reactions, contributing to the available plasma pool for fractionation or transfusion, and employment of pathogen reduction technology. In order to decrease platelet activation for improvement of in vivo viability, PAS should be designed for optimization of aerobic metabolism using compounds such as glucose, acetate, citrate, phosphate, and electrolytes. After a thorough discussion, particularly on the efficacy and regulations, use of the buffy coat method as well as application of a new generation of PAS may likely be the future direction of platelet storage in Korea.
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KEYWORD
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Platelet additive solution, Plasma, Buffy coat method
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